How is combination therapy with ACEI and ARB applied in patients with acute myocardial infarction?
نویسنده
چکیده
ctivation of the renin – angiotensin system (RAS) has a profound effect on the prognosis of patients with myocardial infarction and/or heart failure with reduced ejection fraction (HFREF), as proven by the beneficial effects of angiotensin-converting enzyme inhibitors (ACEIs).1 Because angiotensin II is produced in the ACE-dependent and -independent pathways,2 the addition of AT1 receptor blockers (ARBs) to ACEIs is expected to completely block RAS activity and to improve the prognosis of patients with cardiovascular diseases.
منابع مشابه
Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction.
BACKGROUND There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI). OBJECTIVES This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles,...
متن کاملPatterns of Use of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Among Patients With Acute Myocardial Infarction in China From 2001 to 2011: China PEACE‐Retrospective AMI Study
BACKGROUND Chinese and U.S. guidelines recommend angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blockers (ARBs) for all patients with acute myocardial infarction (AMI) in the absence of contraindications as either a Class I or Class IIa recommendation. Little is known about the use and trends of ACEI/ARB therapy in China over the past decade. METHODS AND RESULTS Using n...
متن کاملEffect of Beta Blockers and Renin–Angiotensin System Inhibitors on Survival in Patients With Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention
Because it remains uncertain whether β-blockers (BBs) and/or renin-angiotensin system inhibitors benefit a broad population of acute myocardial infarction (AMI) patients, we sought to evaluate the effectiveness of these drugs in improving survival for post-AMI patients who underwent a percutaneous coronary intervention (PCI).From the nationwide data of the South Korea National Health Insurance,...
متن کاملمقایسه مهار سه داروئی و دو داروئی سیستم رنین - آنژیوتانسین - آلدوسترون
Received: 19 Feb, 2010 Accepted: 26 May, 2010 Abstract Background & Aims : According to the clinical guidelines on chronic kidney disease with hypertension, combination therapy with multiple renin–angiotensin–aldosterone system (RAAS) blockers have been recommended as standard first-line therapy. To date, dual and triple blockade of the RAAS has been evaluated. The aim of this study was c...
متن کاملAre treatment effects of ACEI and ARB in post-MI patients homogeneous?
he outcome of patients with acute myocardial infarction (MI) has been substantially improved by the introduction of reperfusion therapy and its continuous refinement. Current reperfusion methodology salvages more than 50% of the ischemic myocardium from infarction in approximately half of acute MI patients without cardiogenic shock. 1 However, in 25% of acute MI patients, myocardial salvage by ...
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عنوان ژورنال:
- Circulation journal : official journal of the Japanese Circulation Society
دوره 74 6 شماره
صفحات -
تاریخ انتشار 2010